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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: REST All Species: 13.33
Human Site: T696 Identified Species: 36.67
UniProt: Q13127 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13127 NP_005603.2 1097 121888 T696 P P M E T A Q T E V A Q M G P
Chimpanzee Pan troglodytes XP_526617 1314 145077 T913 P P M E T A Q T E V A Q M G S
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_539282 1110 122364 P744 L E P S P R G P A Q L E T S P
Cat Felis silvestris
Mouse Mus musculus Q8VIG1 1082 117822 S649 S P M D I A K S E P A Q M E V
Rat Rattus norvegicus O54963 1069 117108 T651 S P M D I A Q T E P A Q M D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_420580 871 97283 M517 P A N D T I V M T K K K K K V
Frog Xenopus laevis Q2EI21 1501 166152 S729 M D I E T I S S D L L L Q R E
Zebra Danio Brachydanio rerio Q2EI20 855 95544 G501 K T A K K L K G K T A V K D T
Tiger Blowfish Takifugu rubipres NP_001135958 954 105361 S600 K D K E N Q S S R K K K K G L
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.1 N.A. 74.9 N.A. 64.7 67 N.A. N.A. 52.2 36.5 37.2 35.3 N.A. N.A. N.A. N.A.
Protein Similarity: 100 82.8 N.A. 79.8 N.A. 74.2 76 N.A. N.A. 62.6 51.2 52.5 50.9 N.A. N.A. N.A. N.A.
P-Site Identity: 100 93.3 N.A. 6.6 N.A. 46.6 60 N.A. N.A. 13.3 13.3 6.6 13.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 93.3 N.A. 13.3 N.A. 66.6 66.6 N.A. N.A. 26.6 40 26.6 26.6 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 12 0 0 45 0 0 12 0 56 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 23 0 34 0 0 0 0 12 0 0 0 0 23 0 % D
% Glu: 0 12 0 45 0 0 0 0 45 0 0 12 0 12 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 12 12 0 0 0 0 0 34 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 12 0 23 23 0 0 0 0 0 0 0 0 0 % I
% Lys: 23 0 12 12 12 0 23 0 12 23 23 23 34 12 0 % K
% Leu: 12 0 0 0 0 12 0 0 0 12 23 12 0 0 12 % L
% Met: 12 0 45 0 0 0 0 12 0 0 0 0 45 0 0 % M
% Asn: 0 0 12 0 12 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 34 45 12 0 12 0 0 12 0 23 0 0 0 0 23 % P
% Gln: 0 0 0 0 0 12 34 0 0 12 0 45 12 0 0 % Q
% Arg: 0 0 0 0 0 12 0 0 12 0 0 0 0 12 0 % R
% Ser: 23 0 0 12 0 0 23 34 0 0 0 0 0 12 12 % S
% Thr: 0 12 0 0 45 0 0 34 12 12 0 0 12 0 12 % T
% Val: 0 0 0 0 0 0 12 0 0 23 0 12 0 0 34 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _